A mutant p53 reactivator
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MIRA-1

Item No. 14858

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(1-oxopropoxy)methyl]-1H-pyrrole-2,5-dione
CAS Number
72835-26-8
Synonyms
  • NSC 19630
Molecular Formula
C8H9NO4
Formula Weight
183.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: 18.3 mg/mlEthanol: 18.3 mg/ml
λmax
215 nm
SMILES
O=C1C=CC(N1COC(CC)=O)=O
InChi Code
InChI=1S/C8H9NO4/c1-2-8(12)13-5-9-6(10)3-4-7(9)11/h3-4H,2,5H2,1H3
InChi Key
YXEWPGYLMHXLPS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $117

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    50 mg

    $484

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    Cayman Chemical
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    Product Description

    MIRA-1 is a maleimide-derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline-regulated mutant p53 (IC50 = 10 µM in vitro).1 Treatment of tumor cells with MIRA-1 induces p21, MDM2 and PUMA in a mutant p53-dependent manner.1 At a concentration of 5-10 mg/kg, MIRA-1, alone or in combination with dexamethasone (Item No. 11015), arrested tumor growth in a mouse xenograft model of multiple myeloma.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bykov, V.J.N., Issaeva, N., Zache, N., et al. Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs. The Journal of Biological Chemisty 280(34), 30384-30391 (2005).

    2. Saha, M.N., Chen, Y., Chen, M.H., et al. Small molecule MIRA-1 induces in vitro and in vivo anti-myeloma activity and synergizes with current anti-myeloma agents. Br. J. Cancer 110(9), 2224-2231 (2014).