An IKKβ inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PS-1145

Item No. 14862

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide
CAS Number
431898-65-6
Synonyms
  • IKK Inhibitor X
Molecular Formula
C17H11ClN4O
Formula Weight
322.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
λmax
239, 293, 364 nm
SMILES
O=C(NC1=CC(Cl)=CC2=C1NC3=C2C=CN=C3)C4=CN=CC=C4
InChi Code
InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
InChi Key
JZRMBDHPALEPDM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $36

    Add

    1 mg

    $55

    Add

    5 mg

    $143

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    PS-1145 is an IκB kinase β (IKKβ) inhibitor (IC50 = 88 nM).1 It selectively inhibits IKKβ over a panel of 14 kinases (IC50s = >100 nM for all). PS-1145 also inhibits the IKK complex (IC50 = 100 nM).2 It inhibits the proliferation of MM.1S, U266, and RPMI-8226 myeloma cells when used at concentrations ranging from 1.5 to 50 µM. PS-1145 inhibits TNF-α-induced activation of NF-κB in MM.1S cells in a concentration-dependent manner. It inhibits RANKL-induced differentiation of RAW 264.7 cells into osteoclasts when used at concentrations of 5 and 10 µM.3 PS-1145 (10 µM) inhibits RANKL-induced phosphorylation of IκBα, ERK, and JNK in RAW 264.7 cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hideshima, T., Chauhan, D., Richardson, P., et al. NF-κB as a therapeutic target in multiple myeloma. The Journal of Biological Chemisty 277(19), 16639-16647 (2002).

    2. Castro, A.C., Dang, L.C., Soucy, F., et al. Novel IKK inhibitors: β-carbolines. Bioorg. Med. Chem. Lett. 13(14), 2419-2422 (2003).

    3. Tsunekage, Y., Takeiri, M., Yoshioka, Y., et al. Nasturtium officinale extract suppresses osteoclastogenesis in RAW 264 cells by inhibiting IκB-kinase β. Nat. Prod. Commun. 16(6), 1-9 (2021).