A selective DNA-PK inhibitor
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NU 7441

Item No. 14881

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-(4-dibenzothienyl)-2-(4-morpholinyl)-4H-1-benzopyran-4-one
CAS Number
503468-95-9
Synonyms
  • Ku-57788
Molecular Formula
C25H19NO3S
Formula Weight
413.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMF:PBS (pH 7.2) (1:4): 0.2 mg/mlDMSO: 0.12 mg/ml
λmax
234, 288 nm
SMILES
O=C(C=C(N1CCOCC1)O2)C3=C2C(C4=CC=CC5=C4SC6=C5C=CC=C6)=CC=C3
InChi Code
InChI=1S/C25H19NO3S/c27-21-15-23(26-11-13-28-14-12-26)29-24-17(6-3-9-20(21)24)19-8-4-7-18-16-5-1-2-10-22(16)30-25(18)19/h1-10,15H,11-14H2
InChi Key
JAMULYFATHSZJM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $48

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    10 mg

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    25 mg

    $154

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    Product Description

    NU 7441 is a selective DNA-PK inhibitor with an IC50 value of 14 nM.1 It inhibits other members of the PI3K-related kinase family, including mTOR, PI3K, ataxia telangiectasia mutated (ATM), and ataxia telangiectasia and Rad3 related (ATR) with IC50 values of 1.7, 5, >100, and >100 μM, respectively.1 NU 7441 has been shown to increase the cytotoxicity of ionizing radiation and etoposide (Item No. 12092) in human colon cancer cell lines in vitro and to potentiate the effects of etoposide in mice bearing human colon cancer xenograft tumors in vivo.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leahy, J.J.J., Golding, B.T., Griffin, R.J., et al. Identification of a highly potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor (NU7441) by screening of chromenone libraries. Bioorg. Med. Chem. Lett. 14(24), 6083-6087 (2004).

    2. Zhao, Y., Thomas, H.D., Batey, M.A., et al. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res. 66(10), 5354-5362 (2006).