An AMPA/kainate glutamate receptor antagonist
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Alternative(s)
38281NBQX
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NBQX (sodium salt)

Item No. 14914

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide, disodium salt
CAS Number
479347-86-9
Molecular Formula
C12H6N4O6S • 2Na
Formula Weight
380.2
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mlDMSO: 20 mg/ml
λmax
220, 271, 296, 357, 426 nm
SMILES
[O-]C1=NC2=C(N=C1[O-])C=C([N+]([O-])=O)C3=C2C=CC=C3S(N)(=O)=O.[Na+].[Na+]
InChi Code
InChI=1S/C12H8N4O6S.2Na/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6;;/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22);;/q;2*+1/p-2
InChi Key
SVJKYIUJRJEABK-UHFFFAOYSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $123

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    25 mg

    $289

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    50 mg

    $543

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    100 mg

    $962

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    Product Description

    Ionotropic glutamate receptors can be divided into three groups, depending on whether they are activated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainate, or N-methyl-D-aspartate (NMDA). NBQX is a water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC50 = 0.15 and 4.8 µM, respectively).1 It does not block the NMDA-sensitive glutamate receptor (IC50 = ≥ 90 µM).1 NBQX can be used in isolated neurons, tissues, or in vivo.2,3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sheardown, M.J., Nielsen, E.O., Hansen, A.J., et al. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A neuroprotectant for cerebral ischemia. Science 247(4942), 571-574 (1990).

    2. Sylantyev, S., Savtchenko, L.P., Ermolyuk, Y., et al. Spike-driven glutamate electrodiffusion triggers synaptic potentiation via a homer-dependent mGluR-NMDAR link. Neuron 77(3), 528-541 (2013).

    3. Bertollini, C., Murana, E., Mosca, L., et al. Transient increase in neuronal chloride concentration by neuroactive aminoacids released from glioma cells. Front. Mol. Neurosci. 5, 100 (2012).

    4. Paterson, N.E., Malekiani, S.A., Foreman, M.M., et al. Pharmacological characterization of harmaline-induced tremor activity in mice. Eur. J. Pharmacol. 616(1-3), 73-80 (2009).

    5. Pomierny-Chamiolo, L., Poleszak, E., Pilc, A., et al. NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice. Pharmacol. Rep. 62(6), 1186-1190 (2010).