An AMPA and kainate receptor antagonist
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Alternative(s)
14914NBQX (sodium salt)
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NBQX

Item No. 38281

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4-tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide
CAS Number
118876-58-7
Synonyms
  • FG-9202
Molecular Formula
C12H8N4O6S
Formula Weight
336.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: Slightly solubleDMSO: 20 mg/mlEthanol: Slightly solublePBS (pH 7.2): 10 mg/ml
λmax
216, 257, 286, 380 nm
SMILES
N[S](=O)(C1=CC=CC2=C(NC3=O)C(NC3=O)=CC([N+]([O-])=O)=C21)=O
InChi Code
InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
InChi Key
UQNAFPHGVPVTAL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $68

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    10 mg

    $101

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    25 mg

    $200

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    50 mg

    $366

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    Product Description

    NBQX is an antagonist of AMPA and kainate receptors (IC50s = 0.15 and 4.8 µM, respectively).1 It is selective for these receptors over NMDA receptors (IC50 = ≥90 µM). In vivo, NBQX (20 mg/kg) increases the latency to seizures, decreases the duration of seizures, and reduces seizure severity in a rat model of epilepsy induced by pentylenetetrazole (PTZ; Item No. 18682).2 It also suppresses relapse phase nicotine self-administration in rats.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sheardown, M.J., Nielsen, E.O., Hansen, A.J., et al. 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: A neuroprotectant for cerebral ischemia. Science 247(4942), 571-574 (1990).

    2. Chen, W., Li, Y.-S., Gao, J., et al. AMPA receptor antagonist NBQX decreased seizures by normalization of perineuronal nets. PLoS One 11(11), e0166672 (2016).

    3. Ruda-Kucerova, J., Amchova, P., Siska, F., et al. NBQX attenuates relapse of nicotine seeking but not nicotine and methamphetamine self-administration in rats. World J. Biol. Psychiatry 22(10), 733-743 (2021).