An inhibitor of MAO-B
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Labeled Version(s)
31688Rasagiline-13C3 (mesylate)
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Rasagiline

Item No. 14917

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R)-2,3-dihydro-N-2-propyn-1-yl-1H-inden-1-amine
CAS Number
136236-51-6
Synonyms
  • (R)-(+)-Rasagiline
Molecular Formula
C12H13N
Formula Weight
171.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 10 mg/mlEthanol: 10 mg/mlEthanol:PBS (pH 7.2) (1:9): 0.10 mg/ml
λmax
265, 272 nm
SMILES
C#CCN[C@H]1C2=CC=CC=C2CC1
InChi Code
InChI=1S/C12H13N/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12/h1,3-6,12-13H,7-9H2/t12-/m1/s1
InChi Key
RUOKEQAAGRXIBM-GFCCVEGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $37

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    25 mg

    $46

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    50 mg

    $65

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    100 mg

    $106

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    Product Description

    Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 4.43 nM for rat brain enzyme).1 It is selective for MAO-B over MAO-A (IC50 = 412 nM for rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 µM.2 Rasagiline inhibits rat brain MAO-B in vivo (ED50 = 0.1 mg/kg).1 It reduces cerebral edema in a mouse model of traumatic brain injury.2 Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson’s disease.3 Formulations containing rasagiline have been used in the treatment of Parkinson’s disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Youdim, M.B.H., Gross, A., and Finberg, J.P. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Brit. J. Pharmacol. 132(2), 500-506 (2001).

    2. Youdim, M.B.H., and Weinstock, M. Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R) aminoindan-5-YL)-ethyl methyl carbamate]. Cell. Mol. Neurobiol. 21(6), 555-573 (2001).

    3. Kang, S.S., Ahn, E.H., Zhang, Z., et al. α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson’s disease. EMBO J. 37(12), e98878 (2018).