An internal standard for the quantification of rasagiline
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Unlabeled Version(s)
14917Rasagiline
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Rasagiline-13C3 (mesylate)

Item No. 31688

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(R)-N-(prop-2-yn-1-yl-13C3)-2,3-dihydro-1H-inden-1-amine, monomethanesulfonate
CAS Number
1391052-18-8
Molecular Formula
C9[13C]3H13N • CH3SO3H
Formula Weight
270.3
Purity
≥95%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly solubleMethanol: Slightly soluble
SMILES
CS(=O)(O)=O.[13CH]#[13C][13CH2]N[C@H]1C2=CC=CC=C2CC1
InChi Code
InChI=1S/C12H13N.CH4O3S/c1-2-9-13-12-8-7-10-5-3-4-6-11(10)12;1-5(2,3)4/h1,3-6,12-13H,7-9H2;1H3,(H,2,3,4)/t12-;/m1./s1/i1+1,2+1,9+1;
InChi Key
JDBJJCWRXSVHOQ-UAWGACSXSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $489

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    Product Description

    Rasagiline-13C3 is intended for use as an internal standard for the quantification of rasagiline (Item No. 14917) by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50 = 4.43 nM for the rat brain enzyme).1 It is selective for MAO-B over MAO-A (IC50 = 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 µM.2 Rasagiline inhibits rat brain MAO-B in vivo (ED50 = 0.1 mg/kg).1 It reduces cerebral edema in a mouse model of traumatic brain injury.2 Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson’s disease.3 Formulations containing rasagiline have been used in the treatment of Parkinson’s disease.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Youdim, M.B.H., Gross, A., and Finberg, J.P. Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase B. Brit. J. Pharmacol. 132(2), 500-506 (2001).

    2. Youdim, M.B.H., and Weinstock, M. Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R) aminoindan-5-YL)-ethyl methyl carbamate]. Cell. Mol. Neurobiol. 21(6), 555-573 (2001).

    3. Kang, S.S., Ahn, E.H., Zhang, Z., et al. α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson’s disease. EMBO J. 37(12), e98878 (2018).