A selective focal adhesion kinase inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PF-573228

Item No. 14924

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinone
CAS Number
869288-64-2
Synonyms
  • FAK Inhibitor II
  • Focal Adhesion Kinase Inhibitor II
Molecular Formula
C22H20F3N5O3S
Formula Weight
491.5
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 15 mg/ml
λmax
292 nm
SMILES
[H]N(C1=NC(N(CC2=CC(S(=O)(C)=O)=CC=C2)[H])=C(C(F)(F)F)C=N1)C3=CC(CC4)=C(C=C3)N([H])C4=O
InChi Code
InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30)
InChi Key
HESLKTSGTIBHJU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $110

    Add

    10 mg

    $186

    Add

    50 mg

    $753

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    PF-573228 inhibits FAK with IC50 values of 4 and 30-100 nM for a purified recombinant catalytic fragment of FAK and in cultured cells, respectively.1 It is 50-250-fold selective for FAK over other protein kinases.1 PF-573228 can inhibit chemotactic and haptotactic migration of cells as well as prevent focal adhesion turnover.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Medina, J.F., Haeggström, J., Kumlin, M., et al. Leukotriene A4: Metabolism in different rat tissues. Biochim. Biophys. Acta 961, 203-212 (1988).

    2. Slack-Davis, J.K., Martin, K.H., Tilghman, R.W., et al. Cellular characterization of a novel focal adhesion kinase inhibitor. The Journal of Biological Chemisty 282(20), 14845-14852 (2007).