A cathepsin G inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Cathepsin G Inhibitor I

Item No. 14928

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
P-[2-[3-[[(1-benzoyl-4-piperidinyl)methylamino]carbonyl]-2-naphthalenyl]-1-(1-naphthalenyl)-2-oxoethyl]-phosphonic acid
CAS Number
429676-93-7
Molecular Formula
C36H33N2O6P
Formula Weight
620.6
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
224, 248 nm
SMILES
O=C(N(C1CCN(C(C2=CC=CC=C2)=O)CC1)C)C3=CC4=CC=CC=C4C=C3C(C(C5=CC=CC6=C5C=CC=C6)P(O)(O)=O)=O
InChi Code
InChI=1S/C36H33N2O6P/c1-37(28-18-20-38(21-19-28)35(40)25-11-3-2-4-12-25)36(41)32-23-27-14-6-5-13-26(27)22-31(32)33(39)34(45(42,43)44)30-17-9-15-24-10-7-8-16-29(24)30/h2-17,22-23,28,34H,18-21H2,1H3,(H2,42,43,44)
InChi Key
GNOZQRKYZJSIPZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    500 µg

    $51

    Add

    1 mg

    $97

    Add

    5 mg

    $355

    Add
    Cayman Chemical
    Neutrophil Biology Wall Poster

    Explore how neutrophils shape the immune response in health and disease. This poster highlights neutrophil pathogen defense mechanisms, including phagocytosis, degranulation, and NETosis, as well as neutrophil roles in inflammation and NET-associated pathologies.

    DOWNLOAD NOW
    Product Description

    Cathepsin G inhibitor I is an inhibitor of cathepsin G (IC50 = 53 nM).1 It is selective for cathepsin G over various serine proteases, including thrombin, Factor Xa, Factor IXa, plasmin, trypsin, and leukocyte proteinase 3 (PR3; IC50s = >100 µM for all), but also weakly inhibits chymotrypsin. It inhibits cathepsin G-induced activation of IL-36 in neutrophil degranulates when used at a concentration of 10 µM.2 Cathepsin G inhibitor I (10 µM) reduces CD4+ T cell-induced secretion of IFN-γ and IL-17 in B cells incubated with tetanus toxin C-fragments (TTC) and also reduces TTC presentation in B cells.3 It decreases the size of neuromyelitis optica lesions and reduces the number of perivascular neutrophils, indicating decreased neutrophil brain entry, when used in combination with the neutrophil elastase inhibitor sivelestat (Item No. 17779) in a mouse model of IgG-induced brain injury when administered intracerebrally at a dose of 5 µg/animal.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Greco, M.N., Hawkins, M.J., Powell, E.T., et al. Nonpeptide inhibitors of cathepsin G: Optimization of a novel β-ketophosphonic acid lead by structure-based drug design. J. Am. Chem. Soc. 124(15), 3810-3811 (2002).

    2. Henry, C.M., Sullivan, G.P., Clancy, D.M., et al. Neutrophil-derived proteases escalate inflammation through Aactivation of IL-36 family cytokines. Cell Rep. 14(4), 708-722 (2016).

    3. Reich, M., Lesner, A., Legowska, A., et al. Application of specific cell permeable cathepsin G inhibitors resulted in reduced antigen processing in primary dendritic cells. Mol. Immunol. 46(15), 2994-2999 (2009).

    4. Saadoun, S., Waters, P., MacDonald, C., et al. Neutrophil protease inhibition reduces neuromyelitis optica-immunoglobulin G-induced damage in mouse brain. Ann. Neurol. 71(3), 323-333 (2012).

    Product Citations

    Xiao, Y., Cong, M., Li, J., et al. Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation. Cancer Cell 39(3), 423-437 (2021).