An inhibitor of neutrophil elastase
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Sivelestat (sodium salt hydrate)

Item No. 17779

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2-dimethyl-propanoic acid, 4-[[[2-[[(carboxymethyl)amino]carbonyl]phenyl]amino]sulfonyl]phenyl ester, monosodium salt, tetrahydrate
CAS Number
201677-61-4
Synonyms
  • LY544349
  • ONO-5046
Molecular Formula
C20H21N2O7S • Na [4H2O]
Formula Weight
528.5
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 15 mg/mlEthanol: 0.3 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
210 nm
SMILES
O=S(C1=CC=C(OC(C(C)(C)C)=O)C=C1)(NC2=C(C(NCC([O-])=O)=O)C=CC=C2)=O.[Na+].O.O.O.O
InChi Code
InChI=1S/C20H22N2O7S.Na.4H2O/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24;;;;;/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24);;4*1H2/q;+1;;;;/p-1
InChi Key
PLHREJBSQUSUCW-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $69

    Add

    10 mg

    $120

    Add

    25 mg

    $280

    Add

    50 mg

    $493

    Add
    NET Formation Screening & Analysis Services
    Our experts are here to help.
    • Detection of NET formation ex vivo and screening for modulators using:
      • High-content imaging
      • Enzymatic detection
      • Citrullination/carbamylation detection
    • Experienced scientists skilled in neutrophil biology, isolation, and handling
    LEARN MORE
    Product Description

    Sivelestat is an inhibitor of neutrophil elastase (IC50 = 44 nM for the human enzyme).1 It is selective for neutrophil elastase over trypsin, thrombin, plasmin, kallikrein, chymotrypsin, and cathepsin G at 100 µM. Sivelestat inhibits the formation of neutrophil extracellular traps (NETs) induced by ionomycin (Item Nos. 10004974 | 11932) in isolated mouse neutrophils.2 It decreases LPS-induced NF-κB nuclear translocation in isolated rat pulmonary microvascular endothelial cells (PMVECs) at 50 mM.3 Sivelestat (10 mg/kg) reduces pulmonary edema, increases in the number of cells in the lung tissue positive for myeloperoxidase (MPO), a marker of neutrophil infiltration, and the severity of lung injury in a rat model of LPS-induced acute lung injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Basse, L.H., Groen, D., and Bouwstra, J.A. Permeability and lipid organization of a novel psoriasis stratum corneum substitute. Int. J. Pharm. 457(1), 275-282 (2013).

    2. Martinod, K., Witsch, T., Farley, K., et al. Neutrophil elastase-deficient mice form neutrophil extracellular traps in an experimental model of deep vein thrombosis. J. Thromb. Haemost. 14(3), 551-558 (2016).

    3. Yuan, Q., Jiang, Y.-W., and Fang, Q.-H. Improving effect of Sivelestat on lipopolysaccharide-induced lung injury in rats. APMIS 122(9), 810-817 (2014).