SC-79

SC-79 is an activator of Akt that blocks its membrane translocation while allowing its phosphorylation, in the cytosol, by upstream kinases.¹ For example, both Thr³⁰⁸ and Ser⁴⁷³ on Akt are phosphorylated in serum starved HeLa cells treated for 1 hour with insulin growth factor and SC-79 (4 µg/ml).¹ SC-79 permits phosphorylation and activation of all isoforms of Akt, it is active in multiple cell types, and works in both receptor tyrosine kinase- and G protein-coupled receptor-mediated signaling.¹ SC-79 has been used to elucidate the role of Akt signaling in neuronal survival, glucose-mediated apoptosis in podocytes, and miR-221-regulated cancer cell proliferation.^2,1,3

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1. Jo, H., Mondal, S., Tan, D., et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc. Natl. Acad. Sci. USA 109(26), 10581-10586 (2012).

2. Li, C., and Siragy, H.M. (Pro)renin receptor regulates autophagy and apoptosis in podocytes exposed to high glucose. Am. J. Physiol. Endocrinol. Metab. 309(3), E302-E310 (2015).

3. Yang, W., Yang, Y., Xia, L., et al. MiR-221 promotes capan-2 pancreatic ductal adenocarcinoma cells proliferation by targeting PTEN-Akt. Cell. Physiol. Biochem. 38(6), 2366-2374 (2016).