An antibiotic active against Gram-positive bacteria
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Labeled Version(s)
25038Linezolid-d3
Metabolite(s)
26608PNU 142300
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Linezolid

Item No. 15012

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide
CAS Number
165800-03-3
Synonyms
  • PNU 100766
Molecular Formula
C16H20FN3O4
Formula Weight
337.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 20 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 0.1 mg/ml
λmax
258 nm
SMILES
FC1=C(N2CCOCC2)C=CC(N3C(O[C@@H](CNC(C)=O)C3)=O)=C1
InChi Code
InChI=1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1
InChi Key
TYZROVQLWOKYKF-ZDUSSCGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $94

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    100 mg

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    Product Description

    Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).1 Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.2 Formulations containing linezolid have been used to treat MRSA infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ager, S., and Gould, K. Clinical update on linezolid in the treatment of gram-positive bacterial infections. Infect. Drug Resist. 5, 87-102 (2012).

    2. Pauchard, L.A., Blot, M., Bruyere, T., et al. Linezolid and atorvastatin impact on pneumonia caused by Staphyloccocus aureus in rabbits with or without mechanical ventilation. PLoS One 12(11), e0187187 (2017).