An internal standard for the quantification of linezolid
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Unlabeled Version(s)
15012Linezolid
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Linezolid-d3

Item No. 25038

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[[(5S)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]-acetamide-d3
CAS Number
1127120-38-0
Molecular Formula
C16H17D3FN3O4
Formula Weight
340.4
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mLDMSO: 20 mg/ml
SMILES
FC1=C(N2CCOCC2)C=CC(N3C(O[C@@H](CNC(C([2H])([2H])[2H])=O)C3)=O)=C1
InChi Code
InChI=1S/C16H20FN3O4/c1-11(21)18-9-13-10-20(16(22)24-13)12-2-3-15(14(17)8-12)19-4-6-23-7-5-19/h2-3,8,13H,4-7,9-10H2,1H3,(H,18,21)/t13-/m0/s1/i1D3
InChi Key
TYZROVQLWOKYKF-FUPFOCIHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    500 µg

    $139

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    1 mg

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    5 mg

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    Cayman Chemical
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    Product Description

    Linezolid-d3 is intended for use as an internal standard for the quantification of linezolid (Item No. 15012) by GC- or LC-MS. Linezolid is a synthetic oxazolidinone antibiotic with activity against a wide range of Gram-positive bacteria, including resistant strains of several species, such as methicillin-resistant S. aureus (MRSA), penicillin-resistant pneumococci, vancomycin-resistant enterococci, various anaerobic bacteria, and several mycobacteria and streptococci (MICs = 2-4 mg/ml).1 Linezolid inhibits protein synthesis by binding to domain V of the 23S ribosomal RNA of the 50S subunit of bacterial ribosomes. In vivo, linezolid (50 mg/kg) reduces pulmonary MRSA load in spontaneously breathing and mechanically ventilated rabbits.2 Formulations containing linezolid have been used to treat MRSA infections.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ager, S., and Gould, K. Clinical update on linezolid in the treatment of gram-positive bacterial infections. Infect. Drug Resist. 5, 87-102 (2012).

    2. Pauchard, L.A., Blot, M., Bruyere, T., et al. Linezolid and atorvastatin impact on pneumonia caused by Staphyloccocus aureus in rabbits with or without mechanical ventilation. PLoS One 12(11), e0187187 (2017).