A specific, cell-permeable inhibitor of S6K1
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PF-04708671

Item No. 15018

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole
CAS Number
1255517-76-0
Molecular Formula
C19H21F3N6
Formula Weight
390.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 3 mg/mlEthanol: 2 mg/ml
λmax
256, 282 nm
SMILES
CCC1=CN=CN=C1N(CC2)CCN2CC3=NC4=CC(C(F)(F)F)=CC=C4N3[H]
InChi Code
InChI=1S/C19H21F3N6/c1-2-13-10-23-12-24-18(13)28-7-5-27(6-8-28)11-17-25-15-4-3-14(19(20,21)22)9-16(15)26-17/h3-4,9-10,12H,2,5-8,11H2,1H3,(H,25,26)
InChi Key
FBLPQCAQRNSVHB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $103

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    25 mg

    $240

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    50 mg

    $454

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    100 mg

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    Product Description

    PF-04708671 is a specific, cell-permeable inhibitor of S6K1 (IC50 = 160 nM).1 It does not inhibit S6K2, MSK, or RSK, or many other unrelated kinases, under conditions in which it inhibits S6K1 activity.1 It is useful in evaluating the role of S6K1 and, indirectly, mTORC1, in cell signaling.2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pearce, L.R., Alton, G.R., Richter, D.T., et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). Biochem. J. 431, 245-255 (2010).

    2. Rajan, M.R., Fagerholm, S., Jönsson, C., et al. Phosphorylation of IRS1 at serine 307 in response to insulin in human adipocytes is not likely to be catalyzed by p70 ribosomal S6 kinase. PLoS One 8(4), (2013).

    3. McNamara, C.R., Ahuja, R., Osafo-Addo, A.D., et al. Akt regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis. PLoS One 8(3), (2013).