A phospholipid
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1,2-Distearoyl-sn-glycero-3-PC

Item No. 15100

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2-distearoyl-sn-glycero-3-phosphatidylcholine
CAS Number
816-94-4
Synonyms
  • Coatsome MC 8080
  • 1,2-Distearoyl-sn-glycero-3-Phosphocholine
  • 1,2-DSPC
  • PC(18:0/18:0)
  • 18:0/18:0-PC
Molecular Formula
C44H88NO8P
Formula Weight
790.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 1 mg/ml
SMILES
O=C(CCCCCCCCCCCCCCCCC)OC[C@@H](OC(CCCCCCCCCCCCCCCCC)=O)COP(OCC[N+](C)(C)C)([O-])=O
InChi Code
InChI=1S/C44H88NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h42H,6-41H2,1-5H3/t42-/m1/s1
InChi Key
NRJAVPSFFCBXDT-HUESYALOSA-N
Side Chain Carbon Sum
36:0
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $61

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    500 mg

    $109

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    1 g

    $182

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    Cayman Chemical
    Learn More About Leveraging Helper Lipids to Achieve Versatile LNPs
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    Product Description

    1,2-Distearoyl-sn-glycero-3-PC (1,2-DSPC) is a phospholipid containing the saturated long-chain (18:0) stearic acid inserted at the sn-1 and sn-2 positions. It is commonly used in the generation of micelles, liposomes, and other types of artificial membranes.1,2 The transition temperature of 1,2-DSPC is approximately 55°C in a multilamellar aqueous solution.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Høyrup, P., Mouritsen, O.G., and Jørgensen, K. Phospholipase A2 activity towards vesicles of DPPC and DMPC-DSPC containing small amounts of SMPC. Biochim. Biophys. Acta 1515(2), 133-143 (2001).

    2. Heberle, F.A., and Feigenson, G.W. Phase separation in lipid membranes. Cold Spring Harb. Perspect. Biol. 3(4), 1-13 (2011).

    3. Mabrey, S., and Sturtevant, J.M. Investigation of phase transitions of lipids and lipid mixtures by sensitivity differential scanning calorimetry. Proc. Natl. Acad. Sci. USA 73(11), 3862-3866 (1976).

    Product Citations

    Wojcechowskyj, J.A., Jong, R.M., Mäger, I., et al. Controlling reactogenicity while preserving immunogenicity from a self-amplifying RNA vaccine by modulating nucleocytoplasmic transport. NPJ Vaccines 10(1), 85 (2025).

    Frey, A., Clulo, K., Fei, Y., et al. Targeting an essential viral oncoprotein with an IL-7-enhanced mRNA vaccine induces durable immunity to Merkel cell carcinoma. Cell Rep. 44(10), 116359 (2025).