An inhibitor of influenza neuraminidase
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Labeled Version(s)
30733Zanamivir-13C,15N2 (hydrate)
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Zanamivir

Item No. 15123

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(acetylamino)-4-[(aminoiminomethyl)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-galacto-non-2-enonic acid
CAS Number
139110-80-8
Synonyms
  • GG 167
  • GR 121167X
Molecular Formula
C12H20N4O7
Formula Weight
332.3
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 0.13 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
231 nm
SMILES
O=C(O)C1=C[C@H](NC(N)=N)[C@@H](NC(C)=O)[C@@]([C@H](O)[C@H](O)CO)([H])O1
InChi Code
InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1
InChi Key
ARAIBEBZBOPLMB-UFGQHTETSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Zanamivir is an inhibitor of influenza neuraminidase.1 It inhibits neuraminidase activity in clinical isolates of influenza A subtypes H1N1 and H3N2 and influenza B (geometric mean IC50s = 0.73, 1.64, and 11.21 nM, respectively). Zanamivir inhibits replication of influenza A and B in isolated human respiratory epithelial cells (EC90s = <0.01 mg/L and 0.25-0.54 mg/L, respectively).2 It reduces lung viral titers in mice infected with influenza A or B when administered intranasally at a dose of 0.4 mg/kg. Formulations containing zanamivir have been used in the prevention and treatment of influenza infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ikematsu, H., Kawai, N., Iwaki, N., et al. In vitro neuraminidase inhibitory activity of four neuraminidase inhibitors against clinical isolates of influenza virus in the Japanese 2012-2013 season. J. Infect. Chemother. 21(9), 634-638 (2015).

    2. Waghorn, S.L., and Goa, K.L. Zanamivir. Drugs 55(5), 721-725 (1998).