An internal standard for the quantification of zanamivir
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Unlabeled Version(s)
15123Zanamivir
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Zanamivir-13C,15N2 (hydrate)

Item No. 30733

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(acetylamino)-4-[(amino-15N-imino-15N-methyl-13C)amino]-2,6-anhydro-3,4,5-trideoxy-D-glycero-D-ido-non-2-enonic acid, hydrate
Molecular Formula
C11[13C]H20N2[15N]2O7 • XH2O
Formula Weight
335.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: slightly soluble
SMILES
OC(C1=C[C@H](N[13C]([15NH2])=[15NH])[C@@H](NC(C)=O)[C@@]([C@H](O)[C@H](O)CO)([H])O1)=O
InChi Code
InChI=1S/C12H20N4O7/c1-4(18)15-8-5(16-12(13)14)2-7(11(21)22)23-10(8)9(20)6(19)3-17/h2,5-6,8-10,17,19-20H,3H2,1H3,(H,15,18)(H,21,22)(H4,13,14,16)/t5-,6+,8+,9+,10+/m0/s1/i12+1,13+1,14+1
InChi Key
ARAIBEBZBOPLMB-ZFYKIEQESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    250 µg

    $469

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    Product Description

    Zanamivir-13C,15N2 is intended for use as an internal standard for the quantification of zanamivir (Item No. 15123) by GC- or LC-MS. Zanamivir is a sialic acid analog that inhibits neuraminidase release of newly replicated influenza virus particles.1 It has been shown to selectively inhibit the growth of influenza A and B viruses in plaque reduction assays with IC50 values ranging from 5 to 14 nM and to directly inhibit influenza A and B virus neuraminidases with IC50 values ranging from 0.6 to 7.9 nM in vitro. Intranasal zanamivir administration at 0.4 mg/kg twice daily reduces mortality and viral titers in lung homogenates of mice infected with influenza.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Elliott, M. Zanamivir: From drug design to the clinic. Philos. Trans. R. Soc. Lond. B Biol Sci. 356(1416), 1885-1893 (2001).