FFAR4 (GPR120) (N-Term) Polyclonal Antibody

GPR120 is a G protein-coupled receptor (GPCR) expressed in adipocytes and pro-inflammatory macrophages that is activated by long chain free fatty acids.¹ The activation of GPR120 results in elevated calcium ion and activation of the ERK cascade.¹ ω-3 Fatty acids, such as docosahexaenoic acid and eicosapentaenoic acid initiate GPR120 signaling resulting in inhibition of toll-like receptor and TNF-α inflammatory signaling pathways in a β-arrestin2/TAB1 dependent manner.² The anti-inflammatory effects of GPR120 are indirectly involved with promoting insulin secretion.¹ GPR120 also mediates free fatty acid induced apoptosis inhibition in the enteroendocrin cell line STC-1.¹ Cayman’s N-terminal polyclonal antibody detects GPR120 in LoVo and PC3 cell lysates. The predicted size for GPR120 is 42.2 kDa and the observed size is approximately 45 kDa by western blot.

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1. Katsuma, S., Hatae, N., Yano, T., et al. Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1. The Journal of Biological Chemisty 280(20), 19507-19515 (2005).

2. Oh, D.Y., Talukdar, S., Bae, E.J., et al. GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin sensitizing effects. Cell 142(5), 687-698 (2010).