An HIV-1 protease inhibitor
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Labeled Version(s)
29416Nelfinavir-d3
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Nelfinavir (mesylate)

Item No. 15144

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,4aS,8aS)-N-(1,1-dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy-2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide, monomethanesulfonate
CAS Number
159989-65-8
Synonyms
  • AG-1343
  • Nelfin
Molecular Formula
C32H45N3O4S • CH3SO3H
Formula Weight
663.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 14 mg/mlEthanol: 20 mg/mlEthanol:PBS (pH 7.2)(1:2): 0.33 mg/ml
λmax
253 nm
SMILES
[H][C@]12[C@](CN(C[C@H]([C@H](CSC3=CC=CC=C3)NC(C4=C(C)C(O)=CC=C4)=O)O)[C@H](C(NC(C)(C)C)=O)C2)([H])CCCC1.CS(=O)(O)=O
InChi Code
InChI=1S/C32H45N3O4S.CH4O3S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4;1-5(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39);1H3,(H,2,3,4)/t22-,23+,26-,27-,29+;/m0./s1
InChi Key
NQHXCOAXSHGTIA-SKXNDZRYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    10 mg

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    25 mg

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    50 mg

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    Product Description

    Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM).1 It demonstrates anti-cancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 μM).2 Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaldor, S.W., Kalish, V.J., Davies, J.F., II, et al. Viracept (nelfinavir mesylate, AG1343): A potent, orally bioavailable inhibitor of HIV-1 protease. J. Med. Chem. 40(24), 3979-3985 (1997).

    2. Shim, J.S., Rao, R., Beebe, K., et al. Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir. J. Natl. Cancer Inst. 104(20), 1576-1590 (2012).