An internal standard for the quantification of nelfinavir
Related Products
Unlabeled Version(s)
15144Nelfinavir (mesylate)
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Nelfinavir-d3

Item No. 29416

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3S,4aS,8aS)-N-(tert-butyl)-2-((2R,3R)-2-hydroxy-3-(3-hydroxy-2-(methyl-d3)benzamido)-4-(phenylthio)butyl)decahydroisoquinoline-3-carboxamide
CAS Number
1217629-70-3
Molecular Formula
C32H42D3N3O4S
Formula Weight
570.8
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
O=C(C1=CC=CC(O)=C1C([2H])([2H])[2H])N[C@H]([C@H](O)CN2C[C@](CCCC3)([H])[C@]3([H])C[C@H]2C(NC(C)(C)C)=O)CSC4=CC=CC=C4
InChi Code
InChI=1S/C32H45N3O4S/c1-21-25(15-10-16-28(21)36)30(38)33-26(20-40-24-13-6-5-7-14-24)29(37)19-35-18-23-12-9-8-11-22(23)17-27(35)31(39)34-32(2,3)4/h5-7,10,13-16,22-23,26-27,29,36-37H,8-9,11-12,17-20H2,1-4H3,(H,33,38)(H,34,39)/t22-,23+,26-,27-,29+/m0/s1/i1D3
InChi Key
QAGYKUNXZHXKMR-VWGNXJLPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $436

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    Product Description

    Nelfinavir-d3 is intended for use as an internal standard for the quantification of nelfinavir (Item No. 15144) by GC- or LC-MS. Nelfinavir is an orally bioavailable inhibitor of the HIV-1 protease (Ki =2 nM).1 It demonstrates anticancer activity, selectively preventing the growth of HER2-positive breast cancer cells in vitro by inhibiting Hsp90 (IC50 = 3.1 μM).2 Formulations containing nelfinavir have been used in combination with HIV reverse transcriptase inhibitors for the treatment of HIV infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kaldor, S.W., Kalish, V.J., Davies, J.F., II, et al. Viracept (nelfinavir mesylate, AG1343): A potent, orally bioavailable inhibitor of HIV-1 protease. J. Med. Chem. 40(24), 3979-3985 (1997).

    2. Shim, J.S., Rao, R., Beebe, K., et al. Selective inhibition of HER2-positive breast cancer cells by the HIV protease inhibitor nelfinavir. J. Natl. Cancer Inst. 104(20), 1576-1590 (2012).