An inhibitor of Cdk1
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Ro 3306

Item No. 15149

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5Z-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
CAS Number
872573-93-8
Molecular Formula
C18H13N3OS2
Formula Weight
351.4
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMSO: 20 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.25 mg/ml
λmax
206, 238, 284, 346 nm
SMILES
O=C1/C(SC(NCC2=CC=CS2)=N1)=C/C3=CC=C(N=CC=C4)C4=C3
InChi Code
InChI=1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
InChi Key
XOLMRFUGOINFDQ-YBEGLDIGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $41

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    5 mg

    $99

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    10 mg

    $157

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    50 mg

    $487

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    Product Description

    Ro 3306 is a cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM), two CDK complexes which regulate cell cycling.1 It also inhibits Cdk2 (Ki = 340 nM), PKCδ (Ki = 318 nM), and serum- and glucocorticoid-induce kinase (Ki = 497 nM) but not Cdk4.1 Through its effects on Cdk1, Ro 3306 reversibly arrests proliferating cells at the G2/M phase border, allowing cell synchronization without the use of microtubule poisons.2 Prolonged treatment of cells with Ro 3306 induces apoptosis and this can be augmented in acute myeloid leukemia cells by stimulating p53 activity with nutlin-3.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vassilev, L.T., Tovar, C., Chen, S., et al. Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1. Proc. Natl. Acad. Sci. USA 103(28), 10660-10665 (2006).

    2. Vassilev, L.T. Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1. Cell Cycle 5(22), 2555-2556 (2006).

    3. Kojima, K., Shimanuki, M., Shikami, M., et al. Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML. Cancer Sci. 100(6), 1128-1136 (2009).