An HIV-1 protease inhibitor
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Labeled Version(s)
29585Indinavir-d6
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Indinavir (sulfate)

Item No. 15150

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide, monosulfate
CAS Number
157810-81-6
Synonyms
  • Crixivan
  • L-735,524
  • MK-639
Molecular Formula
C36H47N5O4 • H2SO4
Formula Weight
711.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 14 mg/mlDMSO: 20 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
260 nm
SMILES
O=C([C@H](CC1=CC=CC=C1)C[C@H](O)CN2CCN(CC3=CN=CC=C3)C[C@H]2C(NC(C)(C)C)=O)N[C@@H]4[C@H](O)CC5=C4C=CC=C5.O=S(O)(O)=O
InChi Code
InChI=1S/C36H47N5O4.H2O4S/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43;1-5(2,3)4/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45);(H2,1
InChi Key
NUBQKPWHXMGDLP-BDEHJDMKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Indinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM).1 It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (Kis = 0.24, 15, 50, and 40 nM, respectively).2 Indinavir is active against multiple HIV-1 variants in cell-based assays (IC95s = 12-100 nM).1 Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vacca, J.P., Dorsey, B.D., Schleif, W.A., et al. L-735,524: An orally bioavailable human immunodeficiency virus type 1 protease inhibitor. Proc. Natl. Acad. Sci. USA 91(9), 4096-4100 (1994).

    2. Dorsey, B.D., McDonough, C., McDaniel, S.L., et al. Identification of MK-944a: A second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J. Med. Chem. 43(18), 3386-3399 (2000).