An internal standard for the quantification of indinavir
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Unlabeled Version(s)
15150Indinavir (sulfate)
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Indinavir-d6

Item No. 29585

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinyl-2,4,5,6-d4-methyl-d2)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide
CAS Number
185897-02-3
Synonyms
  • L-735,524-d6
  • MK-639-d6
Molecular Formula
C36H41D6N5O4
Formula Weight
619.8
Purity
≥99% deuterated forms (d1-d6)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: solubleDMSO: solubleMethanol: soluble
SMILES
CC(C)(NC([C@H](C1)N(C[C@H](C[C@H](C(N[C@H]2C3=C(C[C@H]2O)C=CC=C3)=O)CC4=CC=CC=C4)O)CCN1C([2H])([2H])C5=C([2H])N=C([2H])C([2H])=C5[2H])=O)C
InChi Code
InChI=1S/C36H47N5O4/c1-36(2,3)39-35(45)31-24-40(22-26-12-9-15-37-21-26)16-17-41(31)23-29(42)19-28(18-25-10-5-4-6-11-25)34(44)38-33-30-14-8-7-13-27(30)20-32(33)43/h4-15,21,28-29,31-33,42-43H,16-20,22-24H2,1-3H3,(H,38,44)(H,39,45)/t28-,29+,31+,32-,33+/m1/s1/i9D,12D,15D,21D,22D2
InChi Key
CBVCZFGXHXORBI-JYVVPHGCSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Indinavir-d6 is intended for use as an internal standard for the quantification of indinavir (Item No. 15150) by GC- or LC-MS. Indinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM).1 It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (Kis = 0.24, 15, 50, and 40 nM, respectively).2 Indinavir is active against multiple HIV-1 variants in cell-based assays (IC95s = 12-100 nM).1 Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vacca, J.P., Dorsey, B.D., Schleif, W.A., et al. L-735,524: An orally bioavailable human immunodeficiency virus type 1 protease inhibitor. Proc. Natl. Acad. Sci. USA 91(9), 4096-4100 (1994).

    2. Dorsey, B.D., McDonough, C., McDaniel, S.L., et al. Identification of MK-944a: A second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J. Med. Chem. 43(18), 3386-3399 (2000).