An inverse agonist of LRH-1
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ML-179

Item No. 15180

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-2,4(1H,3H)-pyrimidinedione
CAS Number
1883548-87-5
Synonyms
  • CID-45100448
Molecular Formula
C21H25F3N4O2
Formula Weight
422.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 10 mg/ml
λmax
274 nm
SMILES
O=C(N1)N(C2CCCCC2)C(C=C1N(CC3)CCN3C4=CC=CC(C(F)(F)F)=C4)=O
InChi Code
InChI=1S/C21H25F3N4O2/c22-21(23,24)15-5-4-8-17(13-15)26-9-11-27(12-10-26)18-14-19(29)28(20(30)25-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,25,30)
InChi Key
MFABFKUNLDYKGH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    25 mg

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    Cayman Chemical
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    Product Description

    ML-179 is a potent inverse agonist of liver receptor homolog-1 (LRH-1) (IC50 = 320 nM) with maximum efficacy of 40% repression.1 It is inactive at the related steroidogenic factor-1 transcriptional activator.1 Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.12 µM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Busby, S., Nuhant, P., Cameron, M., et al. Discovery of inverse agonists for the liver receptor homologue-1 (LRH1; NR5A2). 1-55 (2010).