An inhibitor of breast cancer stem cells
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ML-243

Item No. 15189

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2E)-N-(4,5-dihydro-2-thiazolyl)-3-(4-ethylphenyl)-2-propenamide
CAS Number
1426576-80-8
Synonyms
  • CID-50910523
Molecular Formula
C14H16N2OS
Formula Weight
260.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 5 mg/ml
λmax
225, 308 nm
SMILES
CCC1=CC=C(/C=C/C(NC2=NCCS2)=O)C=C1
InChi Code
InChI=1S/C14H16N2OS/c1-2-11-3-5-12(6-4-11)7-8-13(17)16-14-15-9-10-18-14/h3-8H,2,9-10H2,1H3,(H,15,16,17)/b8-7+
InChi Key
MTLJBAFNMHPGBV-BQYQJAHWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $130

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    10 mg

    $213

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    25 mg

    $412

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    Cayman Chemical
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    Product Description

    ML-243 is an inhibitor of cancer stem cells, displaying 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC50 = 2.0 µM) over a control (mammary epithelial) cell line (EC50 = 64 µM).1 It weakly antagonizes the adenosine A2A receptor (IC50 = 10 µM) and has no effect on 68 other targets commonly used in drug discovery for lead profiling.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Carmody, L., Germain, A., Morgan, B., et al. Identification of a selective small-molecule inhibitor of breast cancer stem cells - Probe 3. 3, 1-13 (2011).