An ω-3 polyunsaturated fatty acid
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Juniperonic Acid

Item No. 15198

Product Insert (PDF)
Technical Information
Formal Name
5Z,11Z,14Z,17Z-eicosatetraenoic acid
CAS Number
18016-45-0
Synonyms
  • C20:4(5Z,11Z,14Z,17Z)
  • C20:4 n-3
  • FA 20:4
Molecular Formula
C20H32O2
Formula Weight
304.5
Purity
≥90%
Formulation (Request formulation change)
A 1 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/ml
SMILES
CC/C=C\C/C=C\C/C=C\CCCC/C=C\CCCC(O)=O
InChi Code
InChI=1S/C20H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(21)22/h3-4,6-7,9-10,15-16H,2,5,8,11-14,17-19H2,1H3,(H,21,22)/b4-3-,7-6-,10-9-,16-15-
InChi Key
JDKIKEYFSJUYJZ-OUJQXAOTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    2 mg

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    Product Description

    Juniperonic acid is an ω-3 polyunsaturated fatty acid that has been found in plant oils, including those of J. communis.1 Juniperonic acid can be biosynthesized from α-linolenic acid (Item Nos. 90210 | 21910) in C. elegans and reverses growth reductions and lifespan increases in a C. elegans mutant lacking Δ6-desaturase that cannot biosynthesize certain fatty acids, such as arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) and ω-3 arachidonic acid (Item No. 90011).2 It reduces bombesin-induced proliferation of 3T3-Swiss mouse fibroblasts when used at a concentration of 50 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Güvenç, A., Küçükboyaci, N., and Gören, A.C. Fatty acid composition of Juniperus species (Juniperus section) native to Turkey. Nat. Prod. Commun. 7(7), 919-922 (2012).

    2. Guha, S., Calarco, S., Gachet, M.S., et al. Juniperonic acid biosynthesis is essential in Caenorhabditis elegans lacking Δ6 desaturase (fat-3) and generates new ω-3 endocannabinoids. Cells 9(9), 2127 (2020).

    3. Morishige, J., Amano, N., Hirano, K., et al. Inhibitory effect of juniperonic acid (Δ-5c,11c,14c,17c-20:4, ω-3) on bombesin-induced proliferation of Swiss 3T3 cells. Biol. Pharm. Bull. 31(9), 1786-1789 (2008).