An inhibitor of HDAC6
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HDAC6 Inhibitor

Item No. 15200

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,2,3,4-tetrahydro-N-hydroxy-2-[(1-methyl-1H-pyrrol-2-yl)carbonyl]-6-isoquinolinecarboxamide
CAS Number
1259296-46-2
Synonyms
  • Histone Deacetylase 6
Molecular Formula
C16H17N3O3
Formula Weight
299.3
Purity
≥95%
Formulation
A 5 mg/ml solution in acetonitrile
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
SMILES
O=C(NO)C1=CC(CCN(C(C2=CC=CN2C)=O)C3)=C3C=C1
InChi Code
InChI=1S/C16H17N3O3/c1-18-7-2-3-14(18)16(21)19-8-6-11-9-12(15(20)17-22)4-5-13(11)10-19/h2-5,7,9,22H,6,8,10H2,1H3,(H,17,20)
InChi Key
NNQAQGDSGCGFER-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    500 µg

    $63

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    1 mg

    $110

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    5 mg

    $454

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    10 mg

    $783

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    Product Description

    HDAC6 is a predominantly cytoplasmic enzyme that targets α-tubulin, cortactin, and heat shock protein 90, as well as other substrates.1 In this way, it impacts development, proliferation, invasion, and tumorigenesis.1 HDAC6 Inhibitor is a potent and selective inhibitor of HDAC6 (IC50 = 36 nM) that poorly blocks other HDAC enzymes.2 It is cell permeable, inhibiting the acetylation of tubulin in cells with an IC50 value of 210 nM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yang, P.H., Zhang, L., Zhang, Y.J., et al. HDAC6: Physiological function and its selective inhibitors for cancer treatment. Drug Discov.Ther. 7(6), 233-242 (2013).

    2. Blackburn, C., Barrett, C., Chin, J., et al. Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N-hydroxybenzamide with high selectivity for the HDAC6 isoform. J. Med. Chem. 56(18), 7201-7211 (2013).