An HDAC inhibitor
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2-hexyl-4-Pentynoic Acid

Item No. 15205

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(2-propyn-1-yl)-octanoic acid
CAS Number
96017-59-3
Molecular Formula
C11H18O2
Formula Weight
182.3
Purity
≥95%
Formulation
A neat oil
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 20 mg/mlEthanol: 33 mg/mlPBS (pH 7.2): 2 mg/ml
SMILES
C#CCC(C(O)=O)CCCCCC
InChi Code
InChI=1S/C11H18O2/c1-3-5-6-7-9-10(8-4-2)11(12)13/h2,10H,3,5-9H2,1H3,(H,12,13)
InChi Key
DUQSBRQHALCSLC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $49

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    500 mg

    $86

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    1 g

    $132

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    5 g

    $283

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    Product Description

    2-hexyl-4-Pentynoic acid is a derivative of valproic acid (Item No. 13033), an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 µM) than valproic acid (IC50 = 398 µM).1 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 µM.1 It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 µM.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Leng, Y., Marinova, Z., Reis-Fernandes, M.A., et al. Potent neuroprotective effects of novel structural derivatives of valproic acid: Potential roles of HDAC inhibition and HSP70 induction. Neurosci. Lett. 476(3), 127-132 (2010).