An inhibitor of Src, Syk, and platelet aggregation
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MNS

Item No. 15206

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(2-nitroethenyl)-1,3-benzodioxole
CAS Number
1485-00-3
Synonyms
  • 3,4-Methylenedioxy-β-nitrostyrene
  • NSC 10120
  • NSC 105303
  • NSC 170724
  • Syk Inhibitor III
Molecular Formula
C9H7NO4
Formula Weight
193.2
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 33 mg/mlDMSO: 33 mg/mlDMSO:PBS(pH 7.2) (1:2): 0.33 mg/mlEthanol: 0.125 mg/ml
λmax
204, 259, 364 nm
SMILES
O=[N+](/C=C/C1=CC(OCO2)=C2C=C1)[O-]
InChi Code
InChI=1S/C9H7NO4/c11-10(12)4-3-7-1-2-8-9(5-7)14-6-13-8/h1-5H,6H2/b4-3+
InChi Key
KFLWBZPSJQPRDD-ONEGZZNKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $53

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    50 mg

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    100 mg

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    500 mg

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    Product Description

    MNS is a β-nitrostyrene that blocks and reverses platelet aggregation induced by such triggers as collagen, U-46619 (Item No. 16450), and ADP (IC50 = 1.1, 2.1, and 4.1 µM, respectively).1,2 It reduces tyrosine phosphorylation in stimulated platelets and inhibits recombinant human Syk and Src (IC50 = 2.8 and 27.3 µM, respectively) in vitro.1,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, W.Y., Wu, Y.C., and Wu, C.C. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-β-nitrostyrene, a novel tyrosine kinase inhibitor. Mol. Pharmacol. 70(4), 1380-1389 (2006).

    2. Hsieh, P.W., Chang, Y.T., Chuang, W.Y., et al. The synthesis and biologic evaluation of anti-platelet and cytotoxic β-nitrostyrenes. Bioorg. Med. Chem. 18(21), 7621-7627 (2010).

    3. Wang, W.Y., Hsieh, P.W., Wu, Y.C., et al. Synthesis and pharmacological evaluation of novel β-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem. Pharmacol. 74(4), 601-611 (2007).