An inhibitor of LAT1
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BCH

Item No. 15249

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-amino-bicyclo[2.2.1]heptane-2-carboxylic acid
CAS Number
20448-79-7
Synonyms
  • 2-amino-2-Norbornanecarboxylic Acid
Molecular Formula
C8H13NO2
Formula Weight
155.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): 10 mg/ml
SMILES
NC1(C(O)=O)CC2CCC1C2
InChi Code
InChI=1S/C8H13NO2/c9-8(7(10)11)4-5-1-2-6(8)3-5/h5-6H,1-4,9H2,(H,10,11)
InChi Key
MPUVBVXDFRDIPT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $37

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    50 mg

    $70

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    100 mg

    $108

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    250 mg

    $235

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    Product Description

    BCH is an inhibitor of LAT1 that blocks the uptake of L-leucine with an IC50 value of 131.5 µM.1,2 It can inhibit all members of the LAT family at a concentration of 10 mM.3 In addition to eliminating the uptake of neutral amino acids, BCH suppresses mTORC1 signaling that drives DNA synthesis and cell proliferation.3,4 LAT1 is also essential for the uptake of amino acid-related compounds, like L-DOPA (Item No. 13248), through the blood-brain barrier, and this can be inhibited by BCH.2,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fraga, S., Serrao, M.P., and Soares-Da-Silva, P. L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acids. J. Nutr. 132(4), 733-738 (2002).

    2. Kim, D.K., Kanai, Y., Choi, H.W., et al. Characterization of the system L amino acid transporter in T24 human bladder carcinoma cells. Biochim. Biophys. Acta 1565(1), 112-121 (2002).

    3. Wang, Q., and Holst, J. L-type amino acid transport and cancer: Targeting the mTORC1 pathway to inhibit neoplasia. Am. J. Cancer Res. 5(4), 1281-1294 (2015).

    4. Dann, S.G., Selvaraj, A., and Thomas, G. mTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancer. Trends Mol. Med. 13(6), 252-259 (2007).

    5. Kageyama, T., Nakamura, M., Matsuo, A., et al. The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier. Brain Res. 879(1-2), 115-121 (2000).