A non-specific CYP inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

1-Aminobenzotriazole

Item No. 15252

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1H-benzotriazol-1-amine
CAS Number
1614-12-6
Synonyms
  • ABT
  • 3-Aminobenzotriazole
  • 1-Benzotriazolylamine
  • NSC 114498
  • NSC 656987
Molecular Formula
C6H6N4
Formula Weight
134.1
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/mlPBS (pH 7.2): 2 mg/ml
λmax
263 nm
SMILES
NN1C2=CC=CC=C2N=N1
InChi Code
InChI=1S/C6H6N4/c7-10-6-4-2-1-3-5(6)8-9-10/h1-4H,7H2
InChi Key
JCXKHYLLVKZPKE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $41

    Add

    100 mg

    $69

    Add

    250 mg

    $108

    Add

    500 mg

    $196

    Add
    Product Description

    1-aminobenzotriazole (ABT) is a non-specific cytochrome P450 (CYP) inhibitor.1,2,3 It does not appear to affect other enzymes, including UDP-glucuronosyltransferases.4,5 ABT acts as a CYP suicide substrate, producing maximal destruction of hepatic and renal microsome CYP protein in vitro at 10 mM.4 It is effective in vivo, significantly reducing CYP content in both liver and kidney in rats within two hours.4 The effects of ABT on CYP activity is time-dependent, with significant shift in IC50 values with preincubation.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ma, L.-l., Wu, Z.-t., Wang, L., et al. Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity. Acta Pharmacol. Sin. 37(3), 415-424 (2016).

    2. Miyakawa, K., Albee, R., Letzig, L.G., et al. A cytochrome P450-independent mechanism of acetaminophen-induced injury in cultured mouse hepatocytes. J. Pharmacol. Exp. Ther. 354(2), 230-237 (2015).

    3. Emoto, C., Murase, S., Sawada, Y., et al. In vitro inhibitory effect of 1-aminobenzotriazole on drug oxidations in human liver microsomes: A comparison with SKF-525A. Drug Metab. Pharmacokinet. 20(5), 351-357 (2005).

    4. Mugford, C.A., Mortillo, M., Mico, B.A., et al. 1-Aminobenzotriazole-induced destruction of hepatic and renal cytochromes P450 in male Sprague-Dawley rats. Fundam. Appl. Toxicol. 19(1), 43-49 (1992).

    5. Walsky, R.L., Bauman, J.N., Bourcier, K., et al. Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: Altered alamethicin concentration and utility to screen for UGT inhibitors. Drug Metab. Dispos. 40(5), 1051-1065 (2012).