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BI-D1870

Item № 15264
CAS № 501437-28-1
Purity ≥95%
product image
                (CAS 501437-28-1)
SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL
     1 mg $44.00 0.00
     5 mg $165.00 0.00
     10 mg $264.00 0.00

Pricing updated 2019-04-24. Prices are subject to change without notice.

Description

The 90 kDa ribosomal S6 kinases (RSKs) are a group of serine/threonine kinases involved in diverse cellular processes, including growth, survival, and motility.1 BI-D1870 is a cell permeable, ATP-competitive inhibitor of the four vertebrate isoforms of RSK, RSK1-4 (IC50s = 31, 24, 18, and 15 nM, respectively).2 At 100 nM, it also significantly inhibits polo-like kinase 1, Aurora B, maternal embryonic leucine zipper kinase, and mammalian STE20-like kinase 2.2,3 BI-D1870 acts at the N-terminal kinase domain, but not the C-terminal domain, of RSK.2,3

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Technical Information
Formal Name
2-[(3,5-difluoro-4-hydroxyphenyl)amino]-7,8-dihydro-5,7-dimethyl-8-(3-methylbutyl)-6(5H)-pteridinone
CAS Number
501437-28-1
Molecular Formula
C19H23F2N5O2
Formula Weight
391.4
Purity
≥95%
Formulation
A crystalline solid
λmax
211, 279 nm
SMILES
OC1=C(F)C=C(NC2=NC(N(CCC(C)C)C(C)C(N3C)=O)=C3C=N2)C=C1F
InChI Code
InChI=1S/C19H23F2N5O2/c1-10(2)5-6-26-11(3)18(28)25(4)15-9-22-19(24-17(15)26)23-12-7-13(20)16(27)14(21)8-12/h7-11,27H,5-6H2,1-4H3,(H,22,23,24)
InChI Key
DTEKTGDVSARYDS-UHFFFAOYSA-N

Warning - this product is not for human or veterinary use.

Shipping & Storage
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Stability
≥ 2 years
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Additional Information

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References & Product Citations
Product Description References

1. Romeo, Y., Zhang, X., and Roux, P.P. Regulation and function of the RSK family of protein kinases Biochemistry Journal 441(2), 553-569 (2012).

2. Sapkota, G.P., Cummings, L., Newell, F.S., et al. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo Biochemistry Journal 401(1), 29-38 (2007).

3. Bain, J., Plater, L., Elliot, M., et al. The selectivity of protein kinase inhibitors: A further update Biochemistry Journal 408, 297-315 (2007).

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