A PPARβ/δ antagonist
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

GSK0660

Item No. 15272

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[[[2-methoxy-4-(phenylamino)phenyl]amino]sulfonyl]-2-thiophenecarboxylic acid, methyl ester
CAS Number
1014691-61-2
Molecular Formula
C19H18N2O5S2
Formula Weight
418.5
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2)(1:3): 0.25 mg/mlDMSO: 12 mg/mlEthanol: 2 mg/ml
λmax
286 nm
SMILES
O=S(NC(C=C1)=C(OC)C=C1NC2=CC=CC=C2)(C3=C(C(OC)=O)SC=C3)=O
InChi Code
InChI=1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3
InChi Key
NDFKBGWLUHKMFY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $107

    Add

    10 mg

    $201

    Add

    25 mg

    $470

    Add

    50 mg

    $783

    Add
    Product Description

    GSK0660 is the first reported antagonist of PPARβ/δ (IC50 = 155 nM) with no measurable affinity for PPARα or PPARγ (IC50s ≥ 10 μM).1 Because of the limited bioavailability of GSK0660, the related compound GSK3787 (Item No. 15219) was developed as a selective PPARβ/δ antagonist with more suitable pharmacokinetic properties.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shearer, B.G., Steger, D.J., Way, J.M., et al. Identification and characterization of a selective peroxisome proliferator-activated receptor b/d (NR1C2) antagonist. Mol. Endocrinol. 22(2), 523-529 (2008).

    2. Palkar, P.S., Borland, M.G., Naruhn, S., et al. Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-β/δ antagonist GSK3787. Mol. Pharmacol. 78(3), 419-430 (2010).