An inhibitor of adipose triglyceride lipase
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Atglistatin

Item No. 15284

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N’-[4’-(dimethylamino)[1,1’-biphenyl]-3-yl]-N,N-dimethyl-urea
CAS Number
1469924-27-3
Molecular Formula
C17H21N3O
Formula Weight
283.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 25 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 3 mg/ml
λmax
205, 248, 299 nm
SMILES
CN(C)C1=CC=C(C2=CC(NC(N(C)C)=O)=CC=C2)C=C1
InChi Code
InChI=1S/C17H21N3O/c1-19(2)16-10-8-13(9-11-16)14-6-5-7-15(12-14)18-17(21)20(3)4/h5-12H,1-4H3,(H,18,21)
InChi Key
AWOPBSAJHCUSAS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $39

    Add

    5 mg

    $68

    Add

    10 mg

    $116

    Add

    25 mg

    $241

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Atglistatin is a potent, selective, and competitive inhibitor of ATGL (IC50 = 0.7 μM).1 It does not inhibit hormone-sensitive lipase, monoglyceride lipase, pancreatic lipase, lipoprotein lipase, or other lysophospholipases.1 Atglistatin blocks lipolysis by ATGL in vitro, in white adipose tissue organ cultures, and in vivo.1 It does not affect lipolysis in ATGL knockout mice.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mayer, N., Schweiger, M., Romauch, M., et al. Development of small-molecule inhibitors targeting adipose triglyceride lipase. Nat. Chem. Biol. 9(12), 785-787 (2013).

    Product Citations

    Li, H., Dixon, E.E., Wu, H., et al. Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosis. Cell Metab. 34(12), 1977-1998 (2022).

    Patel, R., Santoro, A., Hofer, P., et al. ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. Nature (2021).

    Inazumi, T., Yamada, K., Shirata, N., et al. Prostaglandin E2-EP4 axis promotes lipolysis and fibrosis in adipose tissue leading to ectopic fat deposition and insulin resistance. Cell Rep. 33(2), 108265 (2020).

    Tan, D., Ertunc, M.E., Konduri, S., et al. Discovery of FAHFA-containing triacyglycerols and their metabolic regulation. J. Am. Chem. Soc. 141(22), 8798-8806 (2019).