An ω-7 fatty acid
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trans-Vaccenic Acid

Item No. 15301

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
11E-octadecenoic acid
CAS Number
693-72-1
Synonyms
  • C18:1(11E)
  • C18:1 n-7
  • FA 18:1
  • trans-11-Octadecenoic acid
Molecular Formula
C18H34O2
Formula Weight
282.5
Purity
≥98%
Formulation (Request formulation change)
A 100 mg/ml solution in ethanol
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 100 mg/mlEthanol:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
OC(CCCCCCCCC/C=C/CCCCCC)=O
InChi Code
InChI=1S/C18H34O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-8H,2-6,9-17H2,1H3,(H,19,20)/b8-7+
InChi Key
UWHZIFQPPBDJPM-BQYQJAHWSA-N
Side Chain Carbon Sum
18:1
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    50 mg

    $90

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    100 mg

    $142

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    500 mg

    $436

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    1 g

    $696

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    Product Description

    trans-Vaccenic acid is an ω-7 fatty acid that has been found in bovine milk fats.1 Dietary administration of trans-vaccenic acid (1% w/w) reduces total body fat, mesenteric fat, and adipocyte size, increases inguinal fat mass, and decreases intestinal and hepatic triglyceride secretion in a rat model of obesity with features of metabolic syndrome.2 It decreases hepatocellular ballooning and steatosis, markers of non-alcoholic fatty liver disease (NAFLD), in the same model. Dietary administration of a butter enriched with trans-vaccenic acid decreases serum cholesterol levels and the formation of aortic atherosclerotic lesions in Ldlr-/- mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Santora, J.E., Palmquist, D.L., and Roehrig, K.L. Trans-vaccenic acid is desaturated to conjugated linoleic acid in mice. J. Nutr. 130(2), 208-215 (2000).

    2. Jacome-Sosa, M.M., Borthwick, F., Mangat, R., et al. Diets enriched in trans-11 vaccenic acid alleviate ectopic lipid accumulation in a rat model of NAFLD and metabolic syndrome. J. Nutr. Biochem. 25(7), 692-701 (2014).

    3. Bassett, C.M., Edel, A.L., Patenaude, A.F., et al. Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice. J. Nutr. 140(1), 18-24 (2010).