A p70S6K inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

LY2584702 (tosylate)

Item No. 15320

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[4-[4-[4-fluoro-3-(trifluoromethyl)phenyl]-1-methyl-1H-imidazol-2-yl]-1-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidine, 4-methylbenzenesulfonate
CAS Number
1082949-68-5
Synonyms
  • LYS6K2
Molecular Formula
C21H19F4N7 • C7H8O3S
Formula Weight
617.6
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 20 mg/mlDMSO:PBS (pH 7.2) (1:2): 0.3 mg/mlEthanol: 0.5 mg/ml
λmax
268 nm
SMILES
FC(C(C(F)(F)F)=C1)=CC=C1C2=CN(C)C(C3CCN(C4=C(C=NN5)C5=NC=N4)CC3)=N2.CC6=CC=C(S(=O)(O)=O)C=C6
InChi Code
InChI=1S/C21H19F4N7.C7H8O3S/c1-31-10-17(13-2-3-16(22)15(8-13)21(23,24)25)29-19(31)12-4-6-32(7-5-12)20-14-9-28-30-18(14)26-11-27-20;1-6-2-4-7(5-3-6)11(8,9)10/h2-3,8-12H,4-7H2,1H3,(H,26,27,28,30);2-5H,1H3,(H,8,9,10)
InChi Key
HDYUXDNMHBQKAU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $36

    Add

    5 mg

    $110

    Add

    10 mg

    $203

    Add

    25 mg

    $462

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    LY2584702 is an inhibitor of p70 ribosomal S6 kinase (p70S6K; IC50 = 0.004 µM).1 It is selective for p70S6K over a panel of 83 kinases. LY2584702 inhibits the phosphorylation of S6 in HCT116 colon cancer cells (IC50 = 0.1-0.24 µM) and decreases triglyceride levels and apolipoprotein B secretion in tuberous sclerosis complex 2 (TSC2) knockdown HepG2 cells.1,2 It suppresses self-renewal of primary mouse bone marrow stromal cells when used at a concentration of 2 µM.3 LY2584702 reduces tumor growth in an HCT116 colon cancer mouse xenograft model (ED50 = 2.3 mg/kg).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tolcher, A., Goldman, J., Patnaik, A., et al. A phase I trial of LY2584702 tosylate, a p70 S6 kinase inhibitor, in patients with advanced solid tumours. Eur. J. Cancer 50(5), 867-875 (2014).

    2. Roberts, J.L., He, B., Erickson, A., et al. Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells. Biochim. Biophys. Acta 1861(3), 166-176 (2016).

    3. Gu, X., Fu, X., Lu, J., et al. Pharmacological inhibition of S6K1 impairs self-renewal and osteogenic differentiation of bone marrow stromal cells. J. Cell. Biochem. 119(1), 1041-1049 (2017).