A natural steroid glycoside with diverse effects
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Active Metabolite(s)
2907320(S)-Protopanaxatriol
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Ginsenoside Re

Item No. 15330

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(6α)-20-(β-D-glucopyranosyloxy)-3β,12β-dihydroxydammar-24-en-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside
CAS Number
52286-59-6
Synonyms
  • Chikusetsusaponin IVc
  • NSC 308877
  • Panaxoside Re
  • Sanchinoside Re
Molecular Formula
C48H82O18
Formula Weight
947.2
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 20 mg/mlDMF:PBS (pH 7.2) (1:1): 0.5 mg/mlDMSO: 15 mg/mlEthanol: 5 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]4(C)C[C@H](O[C@@]5([H])[C@H](O[C@@]6([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O)[C@@H](CO)O5)[C@]7([H])[C@@](CC[C@H](O)C7(C)C)(C)[C@@]4([H])C1
InChi Code
InChI=1S/C48H82O18/c1-21(2)11-10-14-48(9,66-42-38(60)35(57)32(54)26(19-49)63-42)23-12-16-46(7)30(23)24(51)17-28-45(6)15-13-29(52)44(4,5)40(45)25(18-47(28,46)8)62-43-39(36(58)33(55)27(20-50)64-43)65-41-37(59)34(56)31(53)22(3)61-41/h11,22-43,49-60H,10,12-20H2,1-9H3/t22-,23-,24+,25-,26+,27+,28+,29-,30-,31-,32+,33+,34+,35-,36-,37+,38+,39+,40-,41-,42-,43+,45+,46+,47+,48-/m0/s1
InChi Key
PWAOOJDMFUQOKB-WCZZMFLVSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $36

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    5 mg

    $120

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    10 mg

    $153

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax.1 Structurally, they are steroid glycosides derived from the triterpene squalene.1 Ginsenoside Re is a panaxatriol saponin that is more abundant in some Panax species (e.g., P. quinquefolium) than others.2 This ginsenoside has diverse in vitro and in vivo effects, including vasorelaxant, antioxidant, antihyperlipidemic, and angiogenic actions.2,3,4,5 Ginsenoside Re improves the effectiveness of chemotherapeutic agents by decreasing the expression of Multidrug Resistance Protein 1 and inhibiting P-glycoprotein.6 Notably, this ginsenoside is converted to other forms in response to steaming or heating plant materials, leading to loss of activity.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liang, Y., and Zhao, S. Progress in understanding of ginsenoside biosynthesis. Plant Biol. (Stuttg) 10(4), 415-421 (2008).

    2. Chen, C.F., Chiou, W.F., and Zhang, J.T. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol. Sin. 29(9), 1103-1108 (2008).

    3. Peng, D., Wang, H., Qu, C., et al. Ginsenoside Re: Its chemistry, metabolism and pharmacokinetics. Chin. Med. 7, 2 (2012).

    4. Han, D.H., Kim, S.H., Higashida, K., et al. Ginsenoside Re rapidly reverses insulin resistance in muscles of high-fat diet fed rats. Metabolism 61(11), 1615-1621 (2012).

    5. Gao, Y., Yang, M.F., Su, Y.P., et al. Ginsenoside Re reduces insulin resistance through activation of PPAR-γ pathway and inhibition of TNF-α production. J. Ethnopharmacol. 147(2), 509-516 (2013).

    6. Helms, S. Cancer prevention and therapeutics: Panax ginseng. Altern. Med. Rev. 9(3), 259-274 (2004).