A natural steroid glycoside with diverse effects
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Isomer(s)
23435Ginsenoside F2
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20(S)-Ginsenoside Rg3

Item No. 15332

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
12β,20-dihydroxydammar-24-en-3β-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
CAS Number
14197-60-5
Synonyms
  • 20(S)-Propanaxadiol
Molecular Formula
C42H72O13
Formula Weight
785.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlEthanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O)(C)[C@]3(C)CC[C@]4([H])[C@@](CC[C@H](O[C@]5([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@@]6([H])[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O6)C4(C)C)(C)[C@@]3([H])C1
InChi Code
InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27
InChi Key
RWXIFXNRCLMQCD-JBVRGBGGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Ginsenosides are pharmacologically active natural constituents of ginseng and other plants of the genus Panax.1 Structurally, they are steroid glycosides derived from the triterpene squalene.1 20(S)-Ginsenoside Rg3 is a panaxadiol found in white and red P. ginseng.2 This ginsenoside has diverse in vitro and in vivo effects, including anti-cancer, neuroprotective, anti-hypertensive, and anti-inflammatory actions.2,3 20(S)-Ginsenoside Rg3 induces apoptosis and inhibits angiogenesis in a variety of cancer models.2,4,5 Notably, this ginsenoside can be produced by heating other ginsenosides, leading to elevated levels in steamed or dried ginseng preparations.2,6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Liang, Y., and Zhao, S. Progress in understanding of ginsenoside biosynthesis. Plant Biol. (Stuttg) 10(4), 415-421 (2008).

    2. Chen, C.F., Chiou, W.F., and Zhang, J.T. Comparison of the pharmacological effects of Panax ginseng and Panax quinquefolium. Acta Pharmacol. Sin. 29(9), 1103-1108 (2008).

    3. Helms, S. Cancer prevention and therapeutics: Panax ginseng. Altern. Med. Rev. 9(3), 259-274 (2004).

    4. Yu, Y., Zhang, C., Liu, L., et al. Hepatic arterial administration of ginsenoside Rg3 and transcatheter arterial embolization for the treatment of VX2 liver carcinomas. Exp. Ther. Med. 5(3), 761-766 (2013).

    5. Liu, T.G., Huang, Y., Cui, D.D., et al. Inhibitory effect of ginsenoside Rg3 combined with gemcitabine on angiogenesis and growth of lung cancer in mice. BMC Cancer 9, 250 (2009).

    6. Kim, I.W., Cha, K.M., Wee, J.J., et al. A new validated analytical method for the quality control of red ginseng products. J. Ginseng Res. 37(4), 475-482 (2013).