A ginsenoside with diverse biological activities
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Ginsenoside F2

Item No. 23435

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,12β)-12-hydroxydammar-24-ene-3,20-diyl bis-β-D-glucopyranoside
CAS Number
62025-49-4
Molecular Formula
C42H72O13
Formula Weight
785.0
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
SMILES
O[C@H]1[C@@]2([H])[C@](CC[C@]2([H])[C@@](CC/C=C(C)/C)(C)O[C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)(C)[C@]4(C)CC[C@]5([H])[C@@](CC[C@H](O[C@]6([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C5(C)C)(C)[C@@]4([H])C1
InChi Code
InChI=1S/C42H72O13/c1-21(2)10-9-14-42(8,55-37-35(51)33(49)31(47)25(20-44)53-37)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,39-,40+,41+,42-/m0/s1
InChi Key
SWIROVJVGRGSPO-JBVRGBGGSA-N
Origin
Plant/Ginseng Radix Et Rhizoma
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Ginsenoside F2 is a ginsenoside that has been found in P. ginseng and has diverse biological activities.1,2,3 It increases the proliferation of human hair dermal papilla cells (HHDPCs) and HaCaT human keratinocytes when used at concentrations of 0.01, 0.1, and 1 μM.1 Ginsenoside F2 (0.5 and 2.5 mg/kg) induces hair growth and increases hair density following depilation in mice. It is cytotoxic to U373MG glioblastoma cells in vitro (IC50 = 50 μg/ml) and reduces tumor growth in a U373MG mouse xenograft model when administered at a dose of 35 mg/kg every other day.2 Ginsenoside F2 (1 mg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.3 It is a human intestinal bacterial metabolite of ginsenoside Rb1 (Item No. 15319) via the intermediate ginsenoside Rd (Item No. 15329).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shin, H.-S., Park, S.-Y., Hwang, E.-S., et al. The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin. Eur. J. Pharmacol. 730, 82-89 (2014).

    2. Shin, J.Y., Lee, J.M., Sin, H.S., et al. Anti-cancer effect of ginsenoside F2 against glioblastoma multiforme in xenograft model in SD rats. J. Ginseng Res. 36(1), 86-92 (2012).

    3. Park, S.-H., Seo, W., Eun, H.S., et al. Protective effects of ginsenoside F2 on 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation in mice. Biochem. Biophys. Res. Commun. 478(4), 1713-1719 (2016).

    4. Kanaoka, M., Akao, T., and Kobashi, K. Metabolism of ginseng saponins, ginsenosides, by human intestinal flora. Wakan Iyakugaku Zasshi 11(3), 241-245 (1994).