An allosteric AMPA receptor antagonist
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Talampanel

Item No. 15341

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(8R)-7-acetyl-5-(4-aminophenyl)-8,9-dihydro-8-methyl-7H-1,3-dioxolo[4,5-h][2,3]benzodiazepine
CAS Number
161832-65-1
Synonyms
  • GYKI 53773
  • LY 300164
Molecular Formula
C19H19N3O3
Formula Weight
337.4
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS (pH 7.2) (1:5): 0.1 mg/mlDMSO: 10 mg/ml
λmax
238, 329 nm
SMILES
NC(C=C1)=CC=C1C2=NN(C(C)=O)[C@H](C)CC3=C2C=C(OCO4)C4=C3
InChi Code
InChI=1S/C19H19N3O3/c1-11-7-14-8-17-18(25-10-24-17)9-16(14)19(21-22(11)12(2)23)13-3-5-15(20)6-4-13/h3-6,8-9,11H,7,10,20H2,1-2H3/t11-/m1/s1
InChi Key
JACAAXNEHGBPOQ-LLVKDONJSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $108

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    10 mg

    $162

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    25 mg

    $270

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    50 mg

    $486

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    Product Description

    Talampanel is an allosteric AMPA receptor antagonist (IC50 = 2.5 µM in cerebellar Purkinje neurons using voltage-clamp electrophysiology).1 It reduces the firing rate of spinal neurons in rats by 68% when administered at a dose of 10 mg/kg following AMPA administration.2 It is protective against seizures in mouse models of epilepsy including maximum electroshock (MES; ED50 = 8.6 mg/kg) and 4-aminopyridine models (Item No. 18511; ED50 = 8.4 mg/kg). It also potentiates the effects of diazepam in MES- and metrazole-induced seizure models when administered at a dose of 2 mg/kg.3 Talampanel is neuroprotective, reducing lesion size in rat and mouse models of focal ischemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bleakman, D., Ballyk, B.A., Schoepp, D.D., et al. Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: Stereospecificity and selectivity profiles. Neuropharmacology 35(12), 1689-1702 (1996).

    2. Lodge, D., Bond, A., O'Neill, M.J., et al. Stereoselective effects-of 2,3-benzodiazepines in vivo: Electrophysiology and neuroprotection studies. Neuropharmacology 35(12), 1681-1688 (1996).

    3. Howes, J.F., and Bell, C. Talampanel. Neurotherapeutics 4(1), 126-129 (2007).