A selective inhibitor of Ubc13
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NSC 697923

Item No. 15346

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(4-methylphenyl)sulfonyl]-5-nitro-furan
CAS Number
343351-67-7
Molecular Formula
C11H9NO5S
Formula Weight
267.3
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble
SMILES
CC1=CC=C(S(C2=CC=C([N+]([O-])=O)O2)(=O)=O)C=C1
InChi Code
InChI=1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3
InChi Key
GAUHIPWCDXOLCZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $26

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    5 mg

    $63

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    25 mg

    $183

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    Cayman Chemical
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    Product Description

    NSC 697923 is a selective inhibitor of the E2 ubiquitin-conjugating enzyme Ubc13 when heterodimerized with Uev1A, blocking polyubiquitin chain formation at concentrations of 0.5 to 2 µM in vitro.1 It also inhibits NF-κB activation by PMA and other agonists, presumably through its effects on Ubc13.1 NSC 697923 blocks proliferation and induces apoptosis in diffuse large B cell lymphoma and neuroblastoma cells.1,2 It has antitumor efficacy in vivo in neuroblastoma orthotopic xenografts, when given intraperitoneally.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pulvino, M., Liang, Y., Oleskyn, D., et al. Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A. Blood 120(8), 1668-1677 (2012).

    2. Cheng, J., Fan, Y.H., Xu, X., et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 5(e1079), (2014).