A selective PTEN inhibitor
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SF1670

Item No. 15368

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(9,10-dihydro-9,10-dioxo-2-phenanthrenyl)-2,2-dimethyl-propanamide
CAS Number
345630-40-2
Molecular Formula
C19H17NO3
Formula Weight
307.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMF:PBS (pH 7.2) (1:3): 0.25 mg/mlDMSO: 10 mg/ml
λmax
213, 279, 448 nm
SMILES
O=C1C2=CC=CC=C2C3=C(C=C(NC(C(C)(C)C)=O)C=C3)C1=O
InChi Code
InChI=1S/C19H17NO3/c1-19(2,3)18(23)20-11-8-9-13-12-6-4-5-7-14(12)16(21)17(22)15(13)10-11/h4-10H,1-3H3,(H,20,23)
InChi Key
VZQDDSYKVYARDW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    Product Description

    Phosphatase and tensin homology on chromosome 10 (PTEN) functions as a key regulatory enzyme in many signal transduction pathways by dephosphorylating proteins and lipids including Akt and phosphatidylinositol 3,4,5-trisphosphate (PIP3). SF1670 specifically binds to the active site of PTEN inhibiting its activity with an IC50 value of 2 μM.1,2 At nanomolar concentrations it increases cellular PIP3 levels, phosphorylation of Akt, and glucose uptake in adipocytes.2,3 Pretreatment with SF1670 has been used to enhance PIP3 signaling in transplanted neutrophils, augmenting their function at sites of infection in neutropenic recipient mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Garlich, J.R., Durden, D.L., Georgiadis, T.M., et al. PTEN inhibitors. PCT/US2005/011626, 1-85 (2005).

    2. Rosivatz, E., Matthews, J.G., McDonald, N.Q., et al. A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem. Biol. 1(12), 780-790 (2006).

    3. Li, Y., Prasad, A., Jia, Y., et al. Pretreatment with phosphatase and tensin homolog deleted on chromosome 10 (PTEN) inhibitor SF1670 augments the efficacy of granulocyte transfusion in a clinically relevant mouse model. Blood 117(24), 6702-6713 (2011).