An antifungal and antitrypanosomal antibiotic
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Venturicidin A

Item No. 15377

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1R,5S,6R,8R,9E,11R,15E,17R)-11-[[3-O-(aminocarbonyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1-hydroxy-5-[(1R,3R,4S,5S)-4-hydroxy-1,3,5-trimethyl-6-oxooctyl]-6,8,16,18-tetramethyl-4,21-dioxabicyclo[15.3.1]heneicosa-9,15,18-trien-3-one
CAS Number
33538-71-5
Synonyms
  • Aabomycin A1
Molecular Formula
C41H67NO11
Formula Weight
750.0
Purity
≥95%
Formulation (Request formulation change)
A lyophilisate
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleEthanol: SolubleMethanol: Soluble
SMILES
CC1=CC[C@](CC(O[C@]([H])([C@@H](C[C@H]([C@@H]([C@@H](C(CC)=O)C)O)C)C)[C@@H]2C)=O)(O[C@@]1(/C(C)=C\CCC[C@@]([H])(O[C@@]([H])(C[C@H]3OC(N)=O)O[C@@H]([C@H]3O)C)/C=C/[C@@H](C2)C)[H])O
InChi Code
InChI=1S/C41H67NO11/c1-10-32(43)29(8)36(45)26(5)20-28(7)38-27(6)19-23(2)15-16-31(50-35-21-33(51-40(42)47)37(46)30(9)49-35)14-12-11-13-24(3)39-25(4)17-18-41(48,53-39)22-34(44)52-38/h13,15-17,23,26-31,33,35-39,45-46,48H,10-12,14,18-22H2,1-9H3,(H2,42,47
InChi Key
HHQKNFDAEDTRJK-KXQVSFSQSA-N
Origin
Bacterium/Streptomyces sp.
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $160

    Add

    5 mg

    $758

    Add
    Cayman Chemical
    Visit Our Environmental Toxicology Resource Center

    Explore additional resources to study natural toxins, pollutants including PFAS and 6-PPD-Q, and their biological effects.

    ENVIRONMENTAL TOXICOLOGY TOOLS & SERVICES
    Product Description

    Venturicidin A is a macrolide antibiotic isolated from strains of Streptomyces.1 It is active against fungi in the genus Venturia which cause apple scab, as well as other fungi, but not against higher plants.1 Venturicidin A is also cytotoxic against trypanosomes (IC50 = 120-540 ng/ml) while being more than 25,000 times less effective against mammalian cells.2 It inhibits bacterial and mitochondrial ATP synthases.3,4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rhodes, A., Fantes, K.H., Boothroyd, B., et al. Venturicidin: A new antifungal antibiotic of potential use in agriculture. Nature 192, 952-954 (1961).

    2. Otoguro, K., Ishiyama, A., Namatame, M., et al. Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites. J. Antibiot. (Tokyo) 61(6), 372-378 (2008).

    3. Perlin, D.S., Latchney, L.R., and Senior, A.E. Inhibition of Escherichia coli H+-ATPase by venturicidin, oligomycin and ossamycin. Biochim. Biophys. Acta 807(3), 238-244 (1985).

    4. Matsuno-Yagi, A., and Hatefi, Y. Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds. The Journal of Biological Chemisty 268(9), 6168-6173 (1993).