Zerumbone

Zerumbone is a natural monocyclic sesquiterpene first isolated from rhizomes of the wild ginger Z. zerumbet.¹ It potently inhibits the activation of Epstein-Barr virus by phorbol esters (IC₅₀ = 140 nM).^1,2 Zerumbone inhibits Sonic hedgehog signaling and induces apoptosis in cancer cell lines.^3,4,5 It has also been shown to have anti-oxidant and anti-inflammatory activities, contributing to immunomodulatory and hepatoprotective effects.⁶

WARNING This product is not for human or veterinary use.

1. Murakami, A., Takahashi, M., Jiwajinda, S., et al. Identification of zerumbone in Zingiber zerumbet smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Biosci. Biotechnol. Biochem. 63(10), 1811-1812 (1999).

2. Murakami, A., Takahashi, D., Kinoshita, T., et al. Zerumbone, a southeast asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: The α,β-unsaturated carbonyl group is a prerequisite. Carcinogenesis 23(5), 795-802 (2002).

3. Stanton, B.Z., and Peng, L.F. Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol. Biosyst. 6(1), 44-54 (2010).

4. Sun, Y., Sheng, Q., Cheng, Y., et al. Zerumbone induces apoptosis in human renal cell carcinoma via Gli-1/Bcl-2 pathway. Pharmazie 68(2), 141-145 (2013).

5. Sehrawat, A., Arlotti, J.A., Murakami, A., et al. Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo. Breast Cancer Res. Treat. 136(2), 429-441 (2012).

6. Rahman, H.S., Rasedee, A., How, C.W., et al. Zerumbone-loaded nanostructured lipid carriers: Preparation, characterization, and antileukemic effect. Int. J. Nanomedicine 8, 2769-2781 (2013).