A sesquiterpene with diverse biological activities
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15400Zerumbone 34294α-Cyperone
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Germacrone

Item No. 30111

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3E,7E)-3,7-dimethyl-10-(1-methylethylidene)-3,7-cyclodecadien-1-one
CAS Number
6902-91-6
Synonyms
  • (E,E)-Germacrone
Molecular Formula
C15H22O
Formula Weight
218.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 20mg/mLDMF:PBS (pH 7.2) (1:8): 0.11mg/mLDMSO: 10mg/mLEthanol: 15mg/mL
SMILES
O=C1/C(C/C=C(C)/CC/C=C(C)/C1)=C(C)\C
InChi Code
InChI=1S/C15H22O/c1-11(2)14-9-8-12(3)6-5-7-13(4)10-15(14)16/h7-8H,5-6,9-10H2,1-4H3/b12-8+,13-7+
InChi Key
CAULGCQHVOVVRN-SWZPTJTJSA-N
Origin
Plant/Curcuma zedoaria
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    5 mg

    $75

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    10 mg

    $134

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    50 mg

    $369

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    100 mg

    $662

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    Product Description

    Germacrone is a sesquiterpene that has been found in gingeraceae plants and has diverse biological activities.1,2,3,4 It inhibits pseudorabies virus (PRV) replication in Vero cells when used at concentrations ranging from 10 to 150 µM.1 Germacrone (50-250 µM) enhances cytotoxicity and apoptosis induced by doxorubicin (Item No. 15007) in doxorubicin-resistant MCF-7/adr cells.2 In vivo, germacrone (5, 10, and 20 mg/kg) reduces body weight gain, visceral fat pad weight, serum insulin and plasma glucose levels, and hepatic lipid levels in a mouse model of high-fat diet-induced obesity.3 It decreases brain malondialdehyde (MDA) levels and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as reduces infarct volume in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. He, W., Zhai, X., Su, J., et al. Antiviral activity of germacrone against pseudorabies virus in vitro. Pathogens 8(4), E258 (2019).

    2. Xie, X.-H., Zhao, H., Hu, Y.-Y., et al. Germacrone reverses adriamycin resistance through cell apoptosis in multidrug-resistant breast cancer cells. Exp. Ther. Med. 8(5), 1611-1615 (2014).

    3. Guo, Y.-R., and Choung, S.-Y. Germacrone attenuates hyperlipidemia and improves lipid metabolism in high-fat diet-induced obese C57BL/6J mice. J. Med. Food 20(1), 46-55 (2017).

    4. Wu, T., Yin, F., Kong, H., et al. Germacrone attenuates cerebral ischemia/reperfusion injury in rats via antioxidative and antiapoptotic mechanisms. J. Cell. Biochem. 120(11), 18901-18909 (2019).