A histone deacetylase inhibitor
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CAY10683

Item No. 15403

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-oxo-4-[(2-phenylethyl)amino]butyl]-carbamic acid, ethyl ester
CAS Number
1477949-42-0
Synonyms
  • Santacruzamate A
Molecular Formula
C15H22N2O3
Formula Weight
278.4
Purity
≥95%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 25 mg/mlEthanol: 30 mg/ml
SMILES
O=C(CCCNC(OCC)=O)NCCC1=CC=CC=C1
InChi Code
InChI=1S/C15H22N2O3/c1-2-20-15(19)17-11-6-9-14(18)16-12-10-13-7-4-3-5-8-13/h3-5,7-8H,2,6,9-12H2,1H3,(H,16,18)(H,17,19)
InChi Key
HTOYBIILVCHURC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $52

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    10 mg

    $81

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    25 mg

    $189

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    50 mg

    $347

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    Cayman Chemical
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    Product Description

    CAY10683 is a potent histone deacetylase (HDAC) inhibitor isolated from the cyanobacterium Symploca.1 It inhibits HDAC2 and HDAC6 with IC50 values of 0.119 and 434 nM, respectively, and is without effect against HDAC4 (IC50 = >1,000 nM).1 CAY10683 inhibits the growth of HCT116 colon cancer cells and HuT-78 cutaneous T cell lymphoma cells (GI50 = 29.4 and 1.4 μM, respectively) more effectively than human dermal fibroblasts (GI50 = >100 μM).1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pavlik, C.M., Wong, C.Y.B., Ononye, S., et al. Santacruzamate A, a potent and selective histone deacetylase inhibitor from the Panamanian marine cyanobacterium cf. Symploca sp. J. Nat. Prod. 76(11), 2026-2033 (2013).