An HMG-CoA reductase inhibitor
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Metabolite(s)
21785Pitavastatin lactone
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Pitavastatin (calcium salt)

Item No. 15414

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid, hemicalcium salt
CAS Number
147526-32-7
Synonyms
  • Itabastatin
  • Itavastatin
  • NKS 104
Molecular Formula
C25H23FNO4 •1/2Ca
Formula Weight
440.5
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMF:PBS(pH 7.2)(1:1): 0.5 mg/mlDMSO: 25 mg/ml
λmax
245 nm
SMILES
[O-]C(C[C@H](O)C[C@H](O)/C=C/C1=C(C2=CC=C(F)C=C2)C3=C(C=CC=C3)N=C1C4CC4)=O.[Ca+2]
InChi Code
InChI=1S/C25H24FNO4.Ca/c26-17-9-7-15(8-10-17)24-20-3-1-2-4-22(20)27-25(16-5-6-16)21(24)12-11-18(28)13-19(29)14-23(30)31;/h1-4,7-12,16,18-19,28-29H,5-6,13-14H2,(H,30,31);/q;+2/p-1/b12-11+;/t18-,19-;/m1./s1
InChi Key
VSQHXQMFUCHGBD-NRFPMOEYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    50 mg

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    100 mg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Pitavastatin is an HMG-CoA reductase inhibitor (Ki = 1.7 nM for the rat liver microsomal enzyme).1 It inhibits sterol biosynthesis in rat liver and ileum (ED50s = 0.13 and 0.2 mg/kg, respectively) and reduces plasma levels of triglycerides and total cholesterol in dogs. Pitavastatin (0.3 mg/kg) increases survival in Dahl salt-sensitive rats fed a high-salt diet, a model of hypertensive heart failure.2 Formulations containing pitavastatin have been used in the treatment of hyperlipidemia, mixed dyslipidemia, and heterozygous familial hypercholesterolemia.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aoki, T., Nishimura, H., Nakagawa, S., et al. Pharmacological profile of a novel synthetic inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Arzneimittelforschung 47(8), 904-909 (1997).

    2. Saka, M., Obata, K., Ichihara, S., et al. Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure. J. Cardiovasc. Pharmacol. 47(6), 770-779 (2006).