A β1-AR antagonist
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Metoprolol (succinate)

Item No. 15429

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
butanedioic acid, compd. with 1-[4-(2-methoxyethyl)phenoxy]-3-[(1-methylethyl)amino]-2-propanol (1:2)
CAS Number
98418-47-4
Molecular Formula
C15H25NO3 • 1/2C4H6O4
Formula Weight
326.4
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 2 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
224, 276 nm
SMILES
COCCC1=CC=C(OCC(O)CNC(C)C)C=C1.O=C(CCC(O)=O)O
InChi Code
InChI=1S/C15H25NO3.C4H6O4/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3;5-3(6)1-2-4(7)8/h4-7,12,14,16-17H,8-11H2,1-3H3;1-2H2,(H,5,6)(H,7,8)
InChi Key
ZBOQQGAVXCUYJM-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    25 mg

    $129

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    50 mg

    $245

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    100 mg

    $460

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    250 mg

    $888

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    Product Description

    Metoprolol is a β1-adrenergic receptor (β1-AR) antagonist (Ki = 47 nM in CHO cells expressing the human receptor).1 It is selective for β1- over β2- and β3-ARs (Kis = 2,730 and >10,000 nM, respectively, in CHO cells expressing the human receptors). Metoprolol (4.7 µM) reduces GTP-induced adenylyl cyclase (AC) activity in CHO cells expressing β1- and β2-ARs. It reduces pulse rate in isolated rat atria in a concentration-dependent manner.2 Metoprolol (10 mg/kg) reduces increased heart rate and mean arterial pressure (MAP) in a rat model of systolic hypertension induced by a fructose-rich diet. Formulations containing metoprolol have been used in the treatment of exercised-induced hypertension, angina, and tachycardia. This product is also available as an analytical reference standard (Item No. 21165).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hoffmann, C., Leitz, M.R., Oberdorf-Maass, S., et al. Comparative pharmacology of human β-adrenergic receptor subtypes—characterization of stably transfected receptors in CHO cells. N.-S. Arch. Pharmacol. 369(2), 151-159 (2004).

    2. Di Verniero, C.A., Silberman, E.A., Mayer, M.A., et al. In vitro and in vivo pharmacodynamic properties of metoprolol in fructose-fed hypertensive rats. J. Cardiovasc. Pharmacol. 51(6), 532-541 (2008).