A PTEN inhibitor
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

bpV(HOpic) (potassium salt) (technical grade)

Item No. 15438

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(5-hydroxy-2-pyridinecarboxylato-κN1,κO2)oxodiperoxy-vanadate(2-), dipotassium
CAS Number
722494-26-0
Synonyms
  • Bisperoxovanadium(HOpic)
Molecular Formula
C6H4NO8V • 2K
Formula Weight
347.2
Purity
≥80%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: 4 mg/mlWater: 4 mg/ml
SMILES
O=[V+3]12([O-][O-]1)([O-][O-]2)([O-]3)[N]4=CC(O)=CC=C4C3=O.[K+].[K+]
InChi Code
InChI=1S/C6H5NO3.2K.2O2.O.V/c8-4-1-2-5(6(9)10)7-3-4;;;2*1-2;;/h1-3,8H,(H,9,10);;;;;;/q;2*+1;2*-2;;+3/p-1
InChi Key
IZLHQXYPQCZJAG-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    bpV(HOpic) is a bisperoxovanadium (bpV) compound that inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 14 nM).1 It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 4.9 μM), and PTP-1βB (IC50 = 25.3 μM).1 At 15 μM, bpV(HOpic) has been shown to protect against stimulated ischemia-reperfusion injury in vitro by decreasing apoptosis and improving cell viability through the upregulation of the PI3K/Akt/eNOS/ERK prosurvival pathway.2

    WARNING This product is not for human or veterinary use.