An NSAID and COX inhibitor
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Labeled Version(s)
33279Oxaprozin-d5
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Oxaprozin

Item No. 15476

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,5-diphenyl-2-oxazolepropanoic acid
CAS Number
21256-18-8
Synonyms
  • NSC 310839
  • Wy 21743
Molecular Formula
C18H15NO3
Formula Weight
293.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:1): 0.5 mg/mlEthanol: 15 mg/ml
λmax
224, 288 nm
SMILES
OC(CCC1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)O1)=O
InChi Code
InChI=1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)
InChi Key
OFPXSFXSNFPTHF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $38

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    10 mg

    $65

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    50 mg

    $129

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    Product Description

    Oxaprozin is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 2.2 and 36 μM for human COX-1 and COX-2, respectively).1 It decreases acetic acid-induced writhing times and carrageenan-induced paw edema in mice when administered at doses of 100 and 70 mg/kg, respectively.2 Formulations containing oxaprozin have been used in the treatment of pain associated with osteoarthritis and rheumatoid arthritis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kawai, S., Nishida, S., Kato, M., et al. Comparison of cyclooxygenase-1 and -2 inhibitory activities of various nonsteroidal anti-inflammatory drugs using human platelets and synovial cells. Eur. J. Pharmacol. 347(1), 87-94 (1998).

    2. Zhou, X.P., Zhang, M.X., Sun, W., et al. Design, synthesis, and in-vivo evaluation of 4,5-diaryloxazole as novel nonsteroidal anti-inflammatory drug. Biol. Pharm. Bull. 32(12), 1986-1990 (2009).